Compound Profile · GH Secretagogue
Ipamorelin
Ipamorelin is a selective GH secretagogue often paired with CJC-1295 in research. It is not approved for human use.
Peptide Score
Evidence
Safety
Regulatory
Transparency
Quick verdict
Cleanest GH secretagogue profile in research — minimal cortisol/prolactin elevation. But not approved for human use anywhere; research-context only.
Reality check
What this isn't
- Not approved for human use in any jurisdiction
- WADA prohibited (S2 — peptide hormones)
- Most commonly studied in combination with CJC-1295, not alone
- Long-term effects on GH axis not characterized in humans
- Selective profile advantage not yet validated vs. real-world superiority
- Injectable peptide; subcutaneous administration
- Educational research review only — not medical advice
Selective GH pulse
GH release profile (no cortisol elevation)
8
Weeks
Preclinical
Trial phase
What this means: Demonstrated selective GH release in human studies without significant cortisol or prolactin elevation, distinguishing it from older secretagogues. Frequently paired with CJC-1295; effectiveness as monotherapy less researched.
What participants experienced
- 1
Administration
GH secretion pulse initiated
- 2
Peak effect
GH elevation without cortisol surge
- 3
Combined use
Often paired with GHRH analogs for synergistic effect
- 4
Research context
Studied for recovery and body composition; never advanced to approval pathway
Full Ipamorelin review
A pentapeptide GH secretagogue acting on the ghrelin/GHS-R.
Selective for GH release with limited cortisol/prolactin elevation in research.
Looking at alternatives?
Compounds with comparable research interest but different evidence, regulatory status, or risk profile.
Growth Hormone
CJC-1295 + Ipamorelin
Why consider it: Combined formulation with stronger research base. More extensively studied together than ipamorelin monotherapy.
View profileGH Releasing
Sermorelin
Why consider it: Older approved GHRH analog. Direct GH stimulation with established safety profile, though lower effect size than ipamorelin.
View profileGH Secretagogue
MK-677 / Ibutamoren
Why consider it: Orally active alternative. Not approved, but oral bioavailability advantage over injectable peptides.
View profile