Verified ComparisonLast updated: 14 April 2026
Best Peptides for Insulin-Resistance Research
Insulin-resistance peptides target incretin and glucagon pathways; this overview ranks by mechanism breadth and evidence.
Retatrutide
Metabolic
4.8/ 5
A+
Tirzepatide
Metabolic
4.6/ 5
A
Editor's note
Retatrutide is next-generation; tirzepatide is approved and established.
| Criterion | Retatrutide | Tirzepatide |
|---|---|---|
| Mechanism breadth | GLP-1 + GIP + glucagon | GLP-1 + GIP |
| Weight loss (secondary to insulin sensitivity) | Highest reported | Robust |
| Approved in Australia | No | Yes |
| Clinical evidence depth | Growing (Phase II/III) | Extensive (approved) |
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