Verified ComparisonLast updated: 12 March 2026
Follistatin-344 vs IGF-1 LR3
Follistatin-344 blocks myostatin and activin signaling. IGF-1 LR3 is a long-acting insulin-like growth factor. Different muscle-growth mechanisms.
Follistatin 344
Recovery
4.0/ 5
B+
IGF-1 LR3
Growth Hormone
4.1/ 5
A−
Editor's note
Follistatin inhibits myostatin (loss of limiting factor); IGF-1 LR3 stimulates growth (gain of signal).
| Criterion | Follistatin 344 | IGF-1 LR3 |
|---|---|---|
| Mechanism | Myostatin inhibition (de-repression) | IGF-1 receptor agonism (direct) |
| Muscle-growth potency | Very high (preclinical) | Very high (preclinical) |
| Bone/metabolic effects | Secondary (myostatin signaling) | Broad (IGF-1 multi-tissue) |
| Preclinical depth | High (myostatin models) | High (IGF-1 models) |
| Systemic vs localized | Can be localized (injection) | Systemic |
Frequently asked questions
Both; complementary mechanisms (myostatin inhibition vs IGF-1 growth signaling).
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