Verified ComparisonLast updated: 22 March 2026
LR3 IGF1-Des vs MK-677
LR3 IGF1-Des is a modified IGF-1 peptide. MK-677 is an oral GH secretagogue mimic. Different routes to growth-factor elevation.
Des(1-3) IGF-1
Growth Hormone
3.8/ 5
B+
MK-677 / Ibutamoren
GH Secretagogue
4.5/ 5
A
Editor's note
LR3 IGF1-Des delivers direct IGF-1; MK-677 stimulates endogenous GH/IGF-1.
| Criterion | Des(1-3) IGF-1 | MK-677 / Ibutamoren |
|---|---|---|
| Mechanism | Direct IGF-1 delivery | GH secretion stimulation |
| Route | Injectable | Oral |
| IGF-1 levels (achieved via) | Direct exogenous | Endogenous GH → IGF-1 |
| Preclinical scope | Growing | Extensive |
| Clinical data | Limited | Some trials |
Frequently asked questions
MK-677 maintains endogenous GH pulsatility; LR3 IGF1-Des is exogenous replacement.
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