Verified Peptide ReviewLast reviewed: 21 April 2026
Compound Profile · Growth Hormone
Des(1-3) IGF-1
Des(1-3) IGF-1 is a modified IGF-1 variant with the D-domain removed, studied in research for anabolic effects with potentially reduced growth-signalling.
LegalResearch onlyEvidenceEmergingHuman useNot approved
6.4/ 10
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Quick verdict
Modified IGF-1 variant studied for improved anabolic selectivity. Human evidence remains very limited.
Reality check
What this isn't
- Not approved for human use — research-only context
- No regulator has approved human use
- Evidence base is early — long-term data limited
- Side-effect profile not fully characterised
- Educational only — not medical advice
Full Des(1-3) IGF-1 review
IGF-1 with amino acids 1-3 removed (D-domain deletion).
Studied for tissue anabolism and muscle growth with potentially reduced mitogenic effects.
Looking at alternatives?
Compounds with comparable research interest but different evidence, regulatory status, or risk profile.