Verified ComparisonLast updated: 22 April 2026
MK-677 vs Ipamorelin
MK-677 (ibutamoren) is a ghrelin receptor mimetic with oral bioavailability. Ipamorelin is an injectable GHS-R agonist. Both aim to stimulate GH release but through different routes.
MK-677 / Ibutamoren
GH Secretagogue
3.9/ 5
B+
Ipamorelin
GH Secretagogue
4.2/ 5
A−
Editor's note
MK-677 has oral availability; ipamorelin is selective but requires injection.
| Criterion | MK-677 / Ibutamoren | Ipamorelin |
|---|---|---|
| Route | Oral | Subcutaneous injection |
| Selectivity for GHS-R | Moderate | Highly selective |
| Mechanism | Ghrelin mimetic | GHS-R agonist |
| Half-life | Short | Very short |
| GH release potency | Dose-dependent | Potent, selective |
Frequently asked questions
Ipamorelin is more selective; MK-677 offers convenience of oral dosing.
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