Verified ComparisonLast updated: 11 April 2026
MT-1 vs Melanotan II
Both are melanocortin-1-receptor agonists studied for pigmentation and tanning. Melanotan II is more potent but has broader systemic effects.
Melanotan I / MT-1
Cosmetic
3.8/ 5
B+
Melanotan II
Cosmetic
3.9/ 5
B+
Editor's note
Melanotan II shows stronger tanning; MT-1 has lower systemic side-effect risk in research models.
| Criterion | Melanotan I / MT-1 | Melanotan II |
|---|---|---|
| MC1R selectivity | Higher selectivity | Non-selective (broad MC activation) |
| Tanning potency | Substantial | Very high |
| Systemic side effects (research) | Lower | Higher (nausea, erectile effects) |
| Regulatory status (AU) | Not approved | Not approved |
| WADA status | Not listed | Not listed |
Frequently asked questions
MT-1's higher selectivity for MC1R may reduce systemic effects, though both activate melanocortin pathways.
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