Verified ComparisonLast updated: 25 April 2026
Retatrutide vs Liraglutide
Retatrutide and liraglutide both target obesity and metabolic disease, but through different mechanisms. Retatrutide combines GLP-1, GIP, and glucagon signalling, while liraglutide acts solely through GLP-1.
Retatrutide
Metabolic
4.8/ 5
A+
Liraglutide
Metabolic
4.2/ 5
A−
Editor's note
Retatrutide shows higher weight-loss potential in trials. Liraglutide has decades of safety and efficacy data.
| Criterion | Retatrutide | Liraglutide |
|---|---|---|
| Mechanism | GLP-1 + GIP + glucagon | GLP-1 only |
| Weight loss in trials | Highest reported in class | Well-established |
| Length of evidence base | Phase II/III | Multi-decade clinical use |
| Safety profile clarity | Accumulating | Well-characterised |
| Regulatory status (AU) | Investigational | Approved |
Frequently asked questions
Liraglutide has decades of use; retatrutide is in active trials.
Want to read the full reviews?