Compound Profile · Skin
GHK-Cu
GHK-Cu is a naturally occurring copper-binding tripeptide that has been studied extensively in skin biology and wound healing literature.
Peptide Score
Evidence
Safety
Regulatory
Transparency
Quick verdict
Most-studied cosmetic peptide for skin biology — topical formulations widely used. Injectable use remains research-only; not approved.
Reality check
What this isn't
- Cosmetic vs. injectable distinction critical — topical widely approved, injectable is not
- Injectable form not approved for human use by TGA or other agencies
- Copper content requires monitoring in injectable forms
- Allergic reactions possible, especially in sensitive individuals
- Topical efficacy superior to injectable in published cosmetic trials
- Long-term systemic effects (injectable) unknown
- Educational research review only — not medical advice
Collagen synthesis stimulation
Gene expression and collagen production (in-vitro)
12
Weeks
Approved
Trial phase
What this means: Extensively documented effects on collagen, elastin and fibroblast activity in cell and tissue models. Multiple topical clinical trials in humans (cosmetic pathway). Injectable form never advanced to clinical approval; long-term human safety uncharacterized.
What participants experienced
- 1
In-vitro studies
Fibroblast collagen synthesis demonstrated
- 2
Topical clinical trials
Cosmetic efficacy and safety documented; regulatory approval for cosmetic use in multiple markets
- 3
Injectable research
Limited human data; systemic effects not established
- 4
Current status
Topical formulations widely available; injectable remains research-only
Full GHK-Cu review
A naturally occurring tripeptide that binds copper(II).
Studied for collagen, elastin and wound healing pathways.
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