Body composition research examines peptides being studied for selective effects on lean and fat mass, muscle quality, and metabolic body phenotype. This page reviews current scientific literature on peptides targeting body composition dynamics and tissue remodelling.
Last updated: 3 May 2026
Body composition research investigates peptides for dual effects on fat loss and lean preservation (GLP-1 agonists with resistance training), selective anabolism (IGF-1-LR3, follistatin), or integrated metabolic remodelling (MK-677 with exercise). Studies examine DXA/DEXA outcomes, muscle quality markers, and metabolic rate changes during weight loss.
GLP-1 RA studies show weight loss with variable lean mass retention, improved with concurrent resistance training. IGF-1-LR3 and follistatin animal studies document lean mass gains, though human athlete data are sparse. MK-677 research suggests muscle mass preservation and improved metabolic rate, though isolated body composition studies are limited.
Most body composition trials focus on obesity/diabetes contexts; lean athletic populations are underexplored. Long-term body composition sustainability after peptide cessation is poorly characterised. Comparative effectiveness of peptides plus training versus training plus nutrition is sparse. Real-world adherence and safety data in athletes are limited.
GLP-1 peptides are ARTG-approved for diabetes/obesity only. IGF-1 and follistatin are not approved for body composition optimisation. Medical practitioners cannot prescribe for athletic body composition enhancement. Research-grade supply is legal for institutional study; personal body recomposition use is not TGA-approved.
Primary research interestMetabolic outcomes & incretin pathway analysis
Widely-prescribed GLP-1 receptor agonist with substantial trial evidence for weight loss and type 2 diabetes.
Primary research interestMetabolic outcomes & incretin pathway analysis
Dual GIP/GLP-1 receptor agonist with strong trial evidence for type 2 diabetes and weight management.
Primary research interestSelective GH release & sleep architecture research
Non-peptide GH secretagogue and ghrelin mimetic studied for muscle growth and recovery.
Primary research interestGrowth hormone axis & body composition research
Long-acting IGF-1 analog studied for muscle growth and recovery in research.
Primary research interestTissue repair & recovery research
Myostatin inhibitor studied for muscle growth by blocking myostatin signalling.