Compound Profile · Longevity
MOTS-c
MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial 12S rRNA gene, studied for its role in metabolic regulation and longevity research.
Peptide Score
Evidence
Safety
Regulatory
Transparency
Quick verdict
Actively researched mitochondrial peptide with mechanistically novel pathway. But human evidence is early-stage; no clinical trials completed.
Reality check
What this isn't
- Research-only status — no approved human clinical use
- No completed randomized controlled trials in humans
- Preclinical (animal) data only for most established claims
- Longevity claims speculative — not established in human lifespan studies
- Mechanistic novelty interesting but not yet validated in human metabolism
- Long-term safety entirely uncharacterized
- Educational research review only — not medical advice
AMPK/insulin sensitivity pathway
Metabolic and mitochondrial effects (preclinical)
Preclinical
Trial phase
What this means: Demonstrated effects on insulin sensitivity and AMPK signaling in animal models. Mechanistically distinct mitochondrial origin. No randomized controlled trials in humans; early-stage human pilot work emerging but not yet published as full trials.
What participants experienced
- 1
Discovery
Identified as encoded within mitochondrial 12S rRNA
- 2
Mechanistic studies
Animal models show insulin sensitivity and AMPK pathway effects
- 3
Early human work
Small pilot studies initiated; full trial data not yet published
- 4
Longevity interest
Research phase only; no clinical trials advancing to approval pathway
Full MOTS-c review
A mitochondrial-derived peptide encoded within mtDNA.
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Why consider it: Metabolic improvement in trials (weight loss, insulin sensitivity) with strong human evidence. More clinically advanced than MOTS-c.
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