PEPTIDE

All Reviews

Peptide Reviews

Independent, evidence-based reviews. Each score reflects the published research, supplier transparency and regulatory clarity at the time of last review.

Reviews
50
Methodology
4-Step Verification
Last Updated
May 2026
Retatrutide
Research only
Evidence
4.8/ 5
A+
Compound profileMetabolic

Retatrutide

Primary research interestMetabolic outcomes & incretin pathway analysis

Next-generation triple hormone receptor agonist showing exceptional potential for weight loss and metabolic improvement.

Last reviewed12 May 2026
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CJC-1295 + Ipamorelin
Research only
Evidence
4.6/ 5
A
Compound profileGrowth Hormone

CJC-1295 + Ipamorelin

Primary research interestGrowth hormone axis & body composition research

Powerful GH secretagogue combination researched for recovery, sleep quality and body composition.

Last reviewed22 Apr 2026
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Prescription
Evidence
4.6/ 5
A
Compound profileMetabolic

Tirzepatide

Primary research interestMetabolic outcomes & incretin pathway analysis

Dual GIP/GLP-1 receptor agonist with strong trial evidence for type 2 diabetes and weight management.

Last reviewed12 Apr 2026
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BPC-157
Research only
Evidence
4.5/ 5
A
Compound profileRecovery

BPC-157

Primary research interestTissue repair & recovery research

Broad healing peptide researched for tissue repair, injury recovery and gut health support.

Last reviewed30 Mar 2026
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Research only
Evidence
4.4/ 5
A
Compound profileRecovery

TB-500

Primary research interestTissue repair & recovery research

Supports tissue repair, reduces inflammation and improves recovery time in research models.

Last reviewed18 Mar 2026
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Tesamorelin
Prescription
Evidence
4.4/ 5
A
Compound profileGH Releasing

Tesamorelin

Primary research interestGHRH-axis pulsatile release research

GHRH analog studied and approved in some jurisdictions for HIV-related lipodystrophy.

Last reviewed2 Apr 2026
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Research only
Evidence
4.4/ 5
A
Compound profileGrowth Hormone

Ipamorelin + Mod GRF 1-29

Primary research interestGrowth hormone axis & body composition research

Modified GRF analog paired with ipamorelin for synergistic GH release in research.

Last reviewed18 Apr 2026
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Prescription
Evidence
4.3/ 5
A−
Compound profileMetabolic

Semaglutide

Primary research interestMetabolic outcomes & incretin pathway analysis

Widely-prescribed GLP-1 receptor agonist with substantial trial evidence for weight loss and type 2 diabetes.

Last reviewed15 Apr 2026
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Research only
Evidence
4.3/ 5
A−
Compound profileGH Secretagogue

Ipamorelin

Primary research interestSelective GH release & sleep architecture research

Selective GH secretagogue with a relatively clean side-effect profile in research literature.

Last reviewed26 Mar 2026
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Research only
Evidence
4.3/ 5
A−
Compound profileGH Releasing

CJC-1295

Primary research interestGHRH-axis pulsatile release research

Long-acting GHRH analog often combined with GH secretagogues in research models.

Last reviewed12 Mar 2026
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Prescription
Evidence
4.2/ 5
A−
Compound profileMetabolic

Liraglutide

Primary research interestMetabolic outcomes & incretin pathway analysis

GLP-1 receptor agonist approved for type 2 diabetes and weight management.

Last reviewed19 Apr 2026
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Prescription
Evidence
4.0/ 5
B+
Compound profileGH Releasing

Sermorelin

Primary research interestGHRH-axis pulsatile release research

Short-acting GHRH analog with a long history of clinical use.

Last reviewed28 Feb 2026
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Research only
Evidence
4.0/ 5
B+
Compound profileSkin

GHK-Cu

Primary research interestDermal collagen synthesis & wound-healing research

Copper tripeptide widely studied for skin and wound healing applications.

Last reviewed4 Mar 2026
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Prescription
Evidence
4.0/ 5
B+
Compound profileImmune

Thymosin Alpha-1

Primary research interestImmune-modulation & inflammation research

Immune-modulating peptide approved in some jurisdictions for hepatitis B and other indications.

Last reviewed22 Mar 2026
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Research only
Evidence
4.0/ 5
B+
Compound profileGH Releasing

Mod GRF 1-29

Primary research interestGHRH-axis pulsatile release research

Short-acting GHRH analog with natural pulsatile-mimicking properties, often combined with GH secretagogues.

Last reviewed22 Apr 2026
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Research only
Evidence
3.8/ 5
B+
Compound profileLongevity

MOTS-c

Primary research interestCellular ageing & mitochondrial research

Mitochondrial-derived peptide studied for metabolic and longevity pathways.

Last reviewed15 Mar 2026
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Research only
Evidence
3.8/ 5
B+
Compound profileGH Secretagogue

MK-677 / Ibutamoren

Primary research interestSelective GH release & sleep architecture research

Non-peptide GH secretagogue and ghrelin mimetic studied for muscle growth and recovery.

Last reviewed8 Apr 2026
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Prescription
Evidence
3.8/ 5
B+
Compound profileCognitive

Cerebrolysin

Primary research interestCognitive performance & neuroprotection research

Peptide-enriched brain extract studied and used clinically for cognitive and neurological indications.

Last reviewed1 Apr 2026
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Research only
Evidence
3.8/ 5
B+
Compound profileRecovery

GHK-Cu + BPC-157 + TB-500 Stack

Primary research interestTissue repair & recovery research

Cosmetic and recovery peptide stack combining collagen support, tissue repair and inflammation modulation.

Last reviewed26 Apr 2026
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Research only
Evidence
3.8/ 5
B+
Compound profileSkin

Matrixyl

Primary research interestDermal collagen synthesis & wound-healing research

Palmitoyl pentapeptide studied for collagen synthesis stimulation in topical cosmetic applications.

Last reviewed11 Apr 2026
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Research only
Evidence
3.8/ 5
B+
Compound profileSkin

Copper Peptides

Primary research interestDermal collagen synthesis & wound-healing research

Copper-binding peptides studied for collagen synthesis, wound healing and antioxidant effects in research.

Last reviewed9 Apr 2026
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Research only
Evidence
3.8/ 5
B+
Compound profileMetabolic

Tesofensine

Primary research interestMetabolic outcomes & incretin pathway analysis

Triple monoamine reuptake inhibitor investigated for weight loss through appetite and energy effects.

Last reviewed23 Apr 2026
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Research only
Evidence
3.6/ 5
B
Compound profileMetabolic

AOD-9604

Primary research interestMetabolic outcomes & incretin pathway analysis

GH fragment originally developed for fat loss; mixed clinical evidence.

Last reviewed10 Feb 2026
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Research only
Evidence
3.6/ 5
B
Compound profileImmune

KPV

Primary research interestImmune-modulation & inflammation research

Tripeptide studied for anti-inflammatory pathways in research models.

Last reviewed15 Feb 2026
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Research only
Evidence
3.6/ 5
B
Compound profileCognitive

Selank

Primary research interestCognitive performance & neuroprotection research

Russian-origin synthetic peptide studied for anxiolytic and cognitive effects.

Last reviewed26 Feb 2026
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Research only
Evidence
3.6/ 5
B
Compound profileGH Secretagogue

Hexarelin

Primary research interestSelective GH release & sleep architecture research

Potent GH secretagogue studied for muscle growth, but with reported cortisol elevation.

Last reviewed28 Mar 2026
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Research only
Evidence
3.6/ 5
B
Compound profileGH Secretagogue

GHRP-2

Primary research interestSelective GH release & sleep architecture research

Potent growth hormone-releasing peptide investigated for GH elevation in research models.

Last reviewed15 Apr 2026
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Research only
Evidence
3.6/ 5
B
Compound profileLongevity

SS-31 / Elamipretide

Primary research interestCellular ageing & mitochondrial research

Mitochondrial-targeting tetrapeptide studied for cellular energy metabolism and cardioprotection.

Last reviewed18 Apr 2026
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Research only
Evidence
3.6/ 5
B
Compound profileCosmetic

Argireline

Primary research interestCosmetic biology & topical research

Hexapeptide investigated for dynamic wrinkle reduction through acetylcholine signaling modulation.

Last reviewed16 Apr 2026
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Research only
Evidence
3.6/ 5
B
Compound profileImmune

Larazotide

Primary research interestImmune-modulation & inflammation research

Tight-junction modulator studied for intestinal barrier function in coeliac disease and inflammatory conditions.

Last reviewed24 Apr 2026
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Research only
Evidence
3.5/ 5
B
Compound profileGH Secretagogue

GHRP-6

Primary research interestSelective GH release & sleep architecture research

Early GH secretagogue investigated for growth hormone release with appetite-related effects.

Last reviewed12 Apr 2026
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Prescription
Evidence
3.4/ 5
B−
Compound profileSexual Health

PT-141

Primary research interestSexual function & melanocortin pathway research

Bremelanotide — a melanocortin receptor agonist approved in some jurisdictions for sexual dysfunction.

Last reviewed8 Mar 2026
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Research only
Evidence
3.4/ 5
B−
Compound profileLongevity

Epitalon

Primary research interestCellular ageing & mitochondrial research

Tetrapeptide studied in longevity literature with modest evidence base.

Last reviewed18 Feb 2026
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Research only
Evidence
3.4/ 5
B−
Compound profileMetabolic

HGH Fragment 176-191

Primary research interestMetabolic outcomes & incretin pathway analysis

C-terminal GH fragment studied for lipolytic effects in research models.

Last reviewed2 Apr 2026
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Research only
Evidence
3.4/ 5
B−
Compound profileGrowth Hormone

IGF-1 LR3

Primary research interestGrowth hormone axis & body composition research

Long-acting IGF-1 analog studied for muscle growth and recovery in research.

Last reviewed22 Mar 2026
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Research only
Evidence
3.4/ 5
B−
Compound profileCognitive

Semax

Primary research interestCognitive performance & neuroprotection research

Russian-origin synthetic peptide studied for cognitive and neuroprotective effects.

Last reviewed30 Mar 2026
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Research only
Evidence
3.4/ 5
B−
Compound profileCosmetic

SNAP-8

Primary research interestCosmetic biology & topical research

Acetylated octapeptide studied for wrinkle reduction through SNARE complex modulation in research.

Last reviewed14 Apr 2026
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Research only
Evidence
3.4/ 5
B−
Compound profileSkin

Lipopeptides

Primary research interestDermal collagen synthesis & wound-healing research

Lipid-conjugated peptides studied for skin and wound-healing applications with enhanced membrane penetration.

Last reviewed25 Apr 2026
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Research only
Evidence
3.2/ 5
B−
Compound profileSleep

DSIP

Primary research interestSleep architecture & circadian research

Delta-sleep-inducing peptide with a long research history but limited modern human evidence.

Last reviewed4 Feb 2026
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Research only
Evidence
3.2/ 5
B−
Compound profileRecovery

Follistatin 344

Primary research interestTissue repair & recovery research

Myostatin inhibitor studied for muscle growth by blocking myostatin signalling.

Last reviewed5 Mar 2026
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Research only
Evidence
3.2/ 5
B−
Compound profileCognitive

Pinealon

Primary research interestCognitive performance & neuroprotection research

Tripeptide studied for pineal gland function and neuroprotection in research.

Last reviewed13 Apr 2026
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Research only
Evidence
3.2/ 5
B−
Compound profileCognitive

Mega-Selank / Extended Semax

Primary research interestCognitive performance & neuroprotection research

Extended-chain variant of Semax investigated for enhanced neuroprotective effects.

Last reviewed20 Apr 2026
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Research only
Evidence
3.2/ 5
B−
Compound profileGrowth Hormone

Des(1-3) IGF-1

Primary research interestGrowth hormone axis & body composition research

IGF-1 variant lacking the D-domain studied for tissue anabolism with reduced mitogenic signalling.

Last reviewed21 Apr 2026
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Research only
Evidence
3.2/ 5
B−
Compound profileCognitive

Dihexa

Primary research interestCognitive performance & neuroprotection research

Neurotropic peptide studied for cognitive and neuroprotective effects through Akt and ERK signalling.

Last reviewed20 Apr 2026
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Research only
Evidence
3.0/ 5
C+
Compound profileLongevity

FOXO4-DRI

Primary research interestCellular ageing & mitochondrial research

Interfering peptide targeting FOXO4 investigated for senescent cell clearance in research.

Last reviewed10 Apr 2026
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Research only
Evidence
3.0/ 5
C+
Compound profileCognitive

Cortagen

Primary research interestCognitive performance & neuroprotection research

Tripeptide investigated for cognitive and stress-resilience effects in research models.

Last reviewed17 Apr 2026
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Research only
Evidence
3.0/ 5
C+
Compound profileCognitive

P21

Primary research interestCognitive performance & neuroprotection research

Dipeptide studied for neuroprotection and cognitive effects in research models.

Last reviewed19 Apr 2026
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Research only
Evidence
2.8/ 5
C
Compound profileMetabolic

Adipotide

Primary research interestMetabolic outcomes & incretin pathway analysis

Peptide targeted to adipose tissue investigated for weight loss through apoptosis.

Last reviewed8 Apr 2026
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Research only
Evidence
2.8/ 5
C
Compound profileCosmetic

Melanotan I / MT-1

Primary research interestCosmetic biology & topical research

Melanocortin-1 receptor agonist studied for pigmentation effects; limited modern research.

Last reviewed26 Apr 2026
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Research only
Evidence
2.6/ 5
C
Compound profileCosmetic

Melanotan II

Primary research interestCosmetic biology & topical research

Synthetic melanocortin analog with significant safety concerns.

Last reviewed22 Feb 2026
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